Cavity Size Estimator Calculator

Model pores, hosts, and solvated cavities with confidence. Choose shape, enter dimensions, get effective diameter. Download clean reports for lab notes and sharing today.

Calculator Inputs

Entered in the selected length unit.
Use crystallographic unit cell volume.
Use less than 100% if partially blocked.
Set 1 if unknown.
Advanced option: guest fit estimate
Estimate how many spherical guests may fit, using packing and occupancy.
Optional
Range: 0 to 0.95
Clear form

Example Data Table

Scenario Inputs Key output
Sphere cavity Radius = 0.50 nm Volume ≈ 0.524 nm³, diameter = 1.00 nm
Cylindrical channel Radius = 0.40 nm, height = 1.20 nm Volume ≈ 0.603 nm³, eq. diameter ≈ 1.04 nm
Ellipsoidal host pocket a=0.60 nm, b=0.45 nm, c=0.35 nm Volume ≈ 0.396 nm³, eq. diameter ≈ 0.91 nm
Crystal void method Unit cell = 25000 ų, void = 48%, cavities = 2 Per cavity ≈ 6000 ų, eq. diameter ≈ 2.24 nm

Formula Used

  • Sphere volume: V = (4/3)πr³, surface area A = 4πr².
  • Cylinder volume: V = πr²h, surface area A = 2πr(r + h).
  • Ellipsoid volume: V = (4/3)πabc. Surface area uses a standard approximation.
  • Box volume: V = L·W·H, surface area A = 2(LW + LH + WH).
  • Void fraction method: Vvoid = Vcell·(φ/100)·(α/100), then Vcavity = Vvoid/N.
  • Equivalent diameter: d = 2·((3V)/(4π))1/3, for a sphere with the same volume.
  • Guest fit estimate: N ≈ ⌊(p·o·Vcavity)/Vguest⌋, using packing p and occupancy o.

How to Use This Calculator

  1. Select a method: Geometry for idealized shapes, or Crystal void fraction for unit-cell based estimates.
  2. Enter your inputs using consistent units, then press Calculate.
  3. Review volume, equivalent diameter, and surface area in the results box.
  4. Optionally estimate guest capacity by entering a guest diameter and packing model.
  5. Use Download CSV or Download PDF to save results for lab notes.

Why cavity volume matters in host–guest chemistry

Cavity volume links structure to function in inclusion complexes, adsorption, and solvated pockets. A spherical cavity with 0.50 nm radius has about 0.524 nm³ volume, matching 524 ų, while its equivalent diameter is 1.00 nm. These numbers help anticipate selectivity, diffusion limits, and whether a guest fits without severe steric strain. Reporting both ų and nm³ improves comparability across crystallography and simulation datasets. To gauge transport, compare cavity diameter with Stokes diameter, allowing 0.1–0.2 nm clearance to represent thermal motion, solvation, and flexibility during diffusion in liquids.

Selecting an idealized geometry that matches reality

Choose the simplest shape that preserves the dominant constraint. Cylinders are useful for channels; with r=0.40 nm and h=1.20 nm, volume is near 0.603 nm³. Ellipsoids capture anisotropy; using a=0.60, b=0.45, c=0.35 nm yields roughly 0.396 nm³. Boxes can approximate voids in frameworks when orthogonal dimensions are known. Consistent units prevent scaling errors during conversion.

From volume to effective diameter and pore class

Different shapes can share the same volume, so an equivalent-sphere diameter offers a common language. The calculator converts V to d = 2·((3V)/(4π))^(1/3). Diameters below 2 nm classify as micropores, 2–50 nm as mesopores, and above 50 nm as macropores. Pair diameter with surface area, because higher area at fixed volume often indicates stronger host–guest contact potential and higher sorption capacity.

Estimating cavity size from crystallographic void fraction

When unit-cell void data are available, compute accessible void volume as Vcell·(void%)·(accessible%). If Vcell is 25000 ų and void is 48%, accessible void is 12000 ų at 100% accessibility. Dividing by two cavities per cell gives 6000 ų per cavity, corresponding to an equivalent diameter near 2.24 nm. This approach is fast for screening porous solids and comparing batches.

Interpreting guest capacity estimates with packing limits

Guest counts are approximate because real molecules are not perfect spheres. The tool models guests as spheres and applies a packing factor p and occupancy o: N ≈ floor(p·o·Vcavity/Vguest). Random packing around 0.64 is conservative, close packing near 0.74 is optimistic, and simple cubic near 0.52 is restrictive. Use occupancy below 100% for blocked entrances or strong binding that reduces free volume.

FAQs

What input units are supported?

Choose a length unit for geometry inputs. The tool converts to meters internally, then reports volume in ų, nm³, and cm³. For void fraction, enter unit-cell volume in ų or nm³ for consistent results.

Which shape should I select?

Use a sphere for roughly isotropic pockets, a cylinder for channels, an ellipsoid for elongated cavities, and a box for orthogonal voids. If unsure, start with a sphere, then compare sensitivity across shapes.

What does equivalent diameter mean?

It is the diameter of a sphere that has the same volume as your selected shape. This normalizes different geometries into one comparable size metric, useful for pore classification and quick screening.

How does the void fraction method work?

It multiplies unit-cell volume by void% and accessible% to get accessible void volume, then divides by cavities per cell. The resulting per-cavity volume is converted to an equivalent diameter and surface area for reporting.

What is the packing factor in guest capacity?

Packing approximates how efficiently spherical guests fill space. Random packing is ~0.64, close packing is ~0.74, and simple cubic is ~0.52. Multiply by occupancy to account for blocked entrances or strong binding.

Why might estimates differ from experiments?

Real cavities are irregular, flexible, and partially solvated, while guests are not perfect spheres. Experimental pore sizes can include connectivity and probe effects. Treat outputs as screening values, then refine with structure models or simulations.

Built for quick estimation and consistent reporting across experiments.

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Important Note: All the Calculators listed in this site are for educational purpose only and we do not guarentee the accuracy of results. Please do consult with other sources as well.