Calculator inputs
This single-page calculator uses a white layout. The page stays single column, while the input area uses a responsive 3-2-1 grid.
Formula used
Lifetime Average Daily Dose (LADD)
LADD = (C × IR × EF × ED × AF × RM) ÷ (BW × AT × 365)
Lifetime cancer risk
Risk = LADD × CSF
Where:
| Symbol | Meaning |
|---|---|
| C | Chemical concentration in the selected medium |
| IR | Daily intake or contact rate |
| EF | Exposure frequency in days per year |
| ED | Exposure duration in years |
| AF | Absorption factor |
| RM | Route multiplier or route adjustment |
| BW | Body weight in kilograms |
| AT | Averaging time in years |
| CSF | Cancer slope factor |
The model is linear with respect to concentration when the other inputs stay constant. That is why the chart forms a straight trend.
How to use this calculator
- Enter the contaminant and choose the main exposure route.
- Provide concentration, intake rate, frequency, and duration values.
- Enter body weight, averaging time, and the correct slope factor.
- Use absorption and route multipliers when your method requires them.
- Set a benchmark risk target for comparison.
- Submit the form to show results, the chart, and the download buttons above the form.
Example data table
| Contaminant | Concentration | Intake Rate | EF | ED | BW | CSF | Estimated Risk |
|---|---|---|---|---|---|---|---|
| Benzene | 0.0002 | 2.0 | 350 | 30 | 70 | 1.5 | 3.52e-6 |
| Arsenic | 0.00005 | 1.8 | 365 | 25 | 60 | 1.2 | 6.43e-7 |
| TCE | 0.0004 | 1.5 | 250 | 20 | 80 | 0.5 | 7.34e-7 |
These rows are illustrative examples for method checking and interface testing.
Important note
This tool is for educational and screening use. It does not diagnose cancer and does not replace site-specific toxicological review, regulatory guidance, or professional judgment.
FAQs
1. What does lifetime cancer risk mean here?
It is the estimated probability of developing cancer from long-term exposure under the assumptions entered into the calculator. It is a screening estimate, not a prediction for any individual person.
2. Why is the slope factor important?
The slope factor converts dose into estimated cancer risk. A larger slope factor produces a larger calculated risk for the same exposure dose.
3. What is LADD?
LADD stands for Lifetime Average Daily Dose. It spreads cumulative exposure across body weight and lifetime averaging time to create a normalized daily dose estimate.
4. Can I use this for inhalation or dermal exposure?
Yes. Choose the relevant route and apply suitable intake, absorption, and route-specific toxicity values. Keep all units internally consistent.
5. What benchmark risk should I enter?
Common screening benchmarks include 1E-6 and 1E-5, but project requirements vary. Use the benchmark that matches your regulatory or technical framework.
6. Why does body weight reduce the calculated dose?
The same amount of chemical exposure is divided across a larger body mass, so the dose per kilogram becomes smaller when body weight increases.
7. Why is the chart linear?
Risk is directly proportional to concentration when all other entries stay unchanged. Doubling concentration doubles dose and doubles the estimated lifetime risk.
8. Does this calculator provide medical advice?
No. It provides a chemistry-based screening estimate only. Medical decisions require qualified clinicians, and risk management decisions may require environmental professionals and regulators.