Analyze dose separation with flexible scientific inputs today. View ratios, margins, and response curves clearly. Make safer comparisons using practical metrics and exportable reports.
This page uses a stacked layout, while the input grid shifts to three, two, or one column based on screen width.
These formulas simplify population response data into screening metrics. Real safety evaluation also depends on variability, route, exposure duration, kinetics, and endpoint selection.
| Compound | ED50 | TD50 | ED99 | TD1 | Min Effective | Min Toxic | TI |
|---|---|---|---|---|---|---|---|
| Compound A | 8 mg/kg | 64 mg/kg | 14 mg/kg | 21 mg/kg | 5 mg/kg | 18 mg/kg | 8.00 |
| Compound B | 4 mg/kg | 12 mg/kg | 7 mg/kg | 9 mg/kg | 3 mg/kg | 8 mg/kg | 3.00 |
| Compound C | 10 µM | 220 µM | 18 µM | 30 µM | 7 µM | 28 µM | 22.00 |
It compares a toxic or lethal midpoint dose with an effective midpoint dose. A larger value suggests wider separation between benefit and harm in a simplified population model.
Some studies report toxicity endpoints, while others report lethality endpoints. This tool supports both so you can match the available dataset and maintain a consistent comparison basis.
Not always. A high index can still hide important risks from variable absorption, metabolism, vulnerable populations, chronic exposure, or different adverse endpoints.
Protective index compares a low-incidence toxicity point, such as TD1 or LD1, with a near-maximal effective point, such as ED99. It often gives a stricter safety view.
It shows how far the low-toxicity threshold sits above ED99, expressed as a percentage. Positive values imply extra room beyond near-maximal effect.
The graph helps visualize how effective and toxic responses move across dose levels. It makes overlap and separation easier to understand than a single ratio alone.
No. This calculator is for educational, screening, and comparative analysis. Clinical decisions require validated studies, patient context, monitoring, and professional oversight.
You need ED50 and at least one toxicity midpoint, either TD50 or LD50. The other fields are optional but improve interpretation and chart detail.
Important Note: All the Calculators listed in this site are for educational purpose only and we do not guarentee the accuracy of results. Please do consult with other sources as well.