Capecitabine Dose Calculator

Plan oral chemo doses with transparent math. Enter height, weight, and creatinine to estimate tablets. Review safety notes and verify dosing before dispensing today.

Calculator

Responsive layout: 3 columns (large), 2 (small), 1 (mobile).

Used for BSA (Mosteller).
Used for BSA and Cockcroft-Gault.
Choose a common starting pattern.
Overrides regimen mg/m² when enabled.
Tablet strengths commonly include 150 mg and 500 mg.
Totals use drug days only (e.g., 14 days on).

Needed for Cockcroft-Gault CrCl estimate.
Female factor applied in Cockcroft-Gault.
Used if manual CrCl not selected.
If enabled, overrides Cockcroft-Gault estimate.
Renal adjustment logic
If CrCl is 30-50 mL/min, starting dose is reduced to 75%. If CrCl < 30 mL/min, capecitabine is contraindicated.
This tool applies only the initial renal adjustment; toxicity-based modifications are protocol-driven.

Example Data Table

CaseHeight (cm)Weight (kg)AgeSexSCr (mg/dL) RegimenEstimated BSA (m²)CrCl (mL/min)Start Dose (mg/m² BID)
11707060M1.0Monotherapy (14 days on, 7 off)~1.82~77.81250
21606072F1.2Combination (14 days on, 7 off)~1.63~39.41000 (then x0.75)
31808555M0.9Lower-dose combination (14 days on, 7 off)~2.06~132.0800
Numbers are approximate and shown for demonstration only.

Formula Used

  • BSA (Mosteller): BSA = √((Height_cm × Weight_kg) / 3600)
  • Dose per administration (BID): Dose_mg = BSA × Dose_mg/m² × RenalFactor
  • RenalFactor (initial): 1.00 if CrCl > 50; 0.75 if CrCl 30-50; contraindicated if CrCl < 30.
  • CrCl (optional, Cockcroft-Gault): ((140 − age) × weight) / (72 × SCr) × 0.85 if female.
Labeling references CrCl determined by Cockcroft-Gault and renal-based starting dose reductions.

How to Use This Calculator

  1. Enter height and weight to compute BSA.
  2. Select a regimen, or enable custom mg/m² if following a protocol.
  3. Provide age, sex, and serum creatinine to estimate CrCl, or enter manual CrCl.
  4. Choose a rounding option to suggest 150 mg and 500 mg tablet combinations.
  5. Press Calculate Dose. The result appears above this form.
  6. Use CSV/PDF downloads to document recent calculations.
Clinical caution
Capecitabine dosing depends on indication, partners, toxicity, organ function, DPD status, and protocol. Always verify with the oncology team.

Body surface area drives starting dose

Many capecitabine protocols dose by body surface area (BSA), reported in square meters. This calculator uses the Mosteller method, BSA = √((height_cm × weight_kg)/3600), because it is widely adopted and easy to audit. A patient at 170 cm and 70 kg has an estimated BSA near 1.82 m², which scales mg/m² regimens into milligram doses per administration.

Common BID regimens and cycle structure

Capecitabine is frequently given twice daily (BID) on treatment days, with planned rest periods. Typical patterns include 14 days on therapy followed by 7 days off, forming a 21‑day cycle, though some protocols use lower continuous doses. The calculator shows per‑dose milligrams, daily total (two doses), and drug‑day totals per cycle so inventory and counseling can be aligned to the intended schedule.

Renal function affects the initial dose

Renal clearance influences exposure. Many product labels recommend no initial reduction when creatinine clearance (CrCl) is above 50 mL/min, a 25% reduction (factor 0.75) when CrCl is 30–50 mL/min, and avoidance when CrCl is below 30 mL/min. The calculator can estimate CrCl using Cockcroft–Gault when age, sex, weight, and serum creatinine are entered, or accept a manual CrCl value from your workflow.

Tablet-strength rounding supports dispensing

Capecitabine tablets are commonly available as 150 mg and 500 mg strengths. Exact calculated doses rarely match tablet totals, so rounding is often required by protocol. The calculator can suggest the closest combination of 150 mg and 500 mg tablets per dose, report the difference (Δ) from the target, and optionally round to the nearest 150 mg before selecting tablets to keep calculations consistent.

Documentation and quality checks

For audit trails, the tool stores recent calculations in the session and exports them to CSV or a simple PDF summary. This supports independent double‑checks: confirm inputs, verify regimen mg/m², confirm CrCl method, and ensure the contraindication screen is respected. Because toxicity‑based modifications depend on clinical assessment and local protocols, use the output as a transparent estimate rather than a prescribing decision. When used consistently, standardized inputs reduce variability between staff members and improve communication with patients about dose timing, missed doses, and storage requirements in busy outpatient clinics.

FAQs

1) Is this a prescribing tool?

No. It produces an educational dose estimate from your inputs and selected regimen. Final orders must follow the treating oncology protocol, labeling, and clinical judgment, including toxicity adjustments and contraindication screening.

2) Which BSA formula is used?

The calculator uses the Mosteller equation: BSA = √((height_cm × weight_kg)/3600). It is commonly used in oncology dosing because it is simple, reproducible, and easy to verify manually.

3) How is renal adjustment applied?

If creatinine clearance is provided, the tool applies an initial factor: 1.00 when CrCl > 50 mL/min, 0.75 when CrCl is 30–50 mL/min, and flags CrCl < 30 mL/min as contraindicated.

4) How is creatinine clearance estimated?

When manual CrCl is not used, the calculator can estimate CrCl with Cockcroft–Gault using age, sex, weight, and serum creatinine. If your site uses a different weight convention, enter a manual CrCl instead.

5) How does tablet rounding work?

Capecitabine tablets are commonly 150 mg and 500 mg. The tool searches practical combinations to find the closest total per dose, reports the difference from the target, and can optionally round to the nearest 150 mg first.

6) What do the CSV and PDF exports include?

Exports contain recent session calculations, including timestamp, regimen, BSA, CrCl, renal factor, selected mg/m², adjusted per-dose milligrams, and the suggested tablet combination. Use them for documentation and double-checks.

Recent Calculation History (saved in session)


No history yet. Run a calculation to store a row.

Related Calculators

Chemo Dose CalculatorBSA Chemo DosingCarboplatin AUC DoseCisplatin Dose ToolMethotrexate Dose ToolCyclophosphamide DosePaclitaxel Dose Calculator5FU Dose CalculatorIrinotecan Dose ToolOxaliplatin Dose Calculator

Important Note: All the Calculators listed in this site are for educational purpose only and we do not guarentee the accuracy of results. Please do consult with other sources as well.