Carboplatin AUC Dose Calculator

Formula used

Calvert equation: Dose (mg) = Target AUC × (GFR + 25). The 25 mL/min term represents non‑renal clearance in the original model. citeturn0search14turn0search3

Cockcroft–Gault estimate: CrCl = ((140 − age) × weight) / (72 × SCr), multiplied by 0.85 for females. citeturn0search1turn0search4 Some guidance caps the renal value (often 125 mL/min) to avoid excessive dosing at very high clearances. citeturn0search18turn0search10

How to use this calculator

1. Enter the target AUC required by the regimen.
2. Select measured clearance or the Cockcroft–Gault estimate.
3. If estimating, enter age, sex, weight, and serum creatinine (plus height for ideal/adjusted weight).
4. Apply capping only if your protocol specifies it.
5. Review the dose and export PDF/CSV for documentation.

Important: This page provides an educational estimate only and does not replace clinical judgment. Always follow institutional dosing, rounding, and safety checks.

Example data table

Why AUC matters for carboplatin exposure

AUC links dose to exposure. It supports predictable drug effect. Many regimens use AUC 4 to 6. Some use higher targets in selected protocols. Exposure changes with kidney clearance.

Calvert equation inputs and the 25 constant

The calculator applies Dose = AUC × (GFR + 25). The 25 term reflects non‑renal clearance. It keeps the model stable at low renal function. Dose rises when GFR rises. Dose also rises when AUC increases.

Renal function options for dosing

You can enter a measured GFR or CrCl. You can also estimate CrCl using Cockcroft–Gault. The estimate needs age, sex, weight, and serum creatinine. It is used widely in oncology workflows. Measured values can be preferred when available.

Creatinine units and clean data entry

Serum creatinine is accepted in mg/dL or µmol/L. The conversion uses 88.4. Clear units reduce errors. Avoid rounding serum creatinine early. Keep lab values as reported. Apply rounding only to the final dose, per policy.

Weight handling for Cockcroft–Gault estimates

The tool supports actual, ideal, and adjusted weight. Ideal weight uses height and sex. Adjusted weight uses IBW + 0.4×(ABW−IBW). This helps in large body size. Local rules differ. Always follow your protocol.

Capping, safety checks, and documentation

Some services cap the renal value at 125 mL/min. This can limit very high doses. It is protocol driven. Record the AUC, method, and cap setting. Export the CSV or PDF for audits. Recheck inputs before prescribing.

FAQs

1) What does this calculator output?

It outputs an estimated carboplatin dose in mg using a target AUC and a renal value. It also shows the renal value used and the method applied.

2) Should I use measured GFR or an estimate?

Use a measured renal value when your workflow provides it. Otherwise, the Cockcroft–Gault estimate is common. Follow institutional guidance for which value drives dosing.

3) Why is there an option to cap GFR or CrCl?

Some protocols cap high clearances, often at 125 mL/min. This can reduce extreme doses in very high renal function. Use capping only when your regimen specifies it.

4) Does the tool adjust for body surface area?

No. Calvert dosing uses renal function rather than body surface area. Weight and height are used only for the renal estimate when Cockcroft–Gault is selected.

5) How should I round the final dose?

Rounding rules vary by pharmacy policy. Many sites round to vial size or a fixed increment. This page reports a whole‑mg estimate. Apply your institutional rounding after review.

6) Is this tool a substitute for clinical judgment?

No. It supports calculation and documentation. It cannot evaluate comorbidities, lab trends, or regimen specifics. Always verify inputs and confirm the final dose with a qualified clinician.