Calculator Inputs
Enter route, unknown toxicity percentage, and up to six ingredients.
Example Data Table
This example uses the oral route with category-to-point conversion and a small unknown fraction.
| Ingredient | Concentration % | Input type | Input value | ATE used |
|---|---|---|---|---|
| Reactant A | 18 | Category | Category 3 | 100 mg/kg bodyweight |
| Solvent B | 6 | Direct ATE | 45 | 45 mg/kg bodyweight |
| Catalyst C | 4 | Category | Category 2 | 5 mg/kg bodyweight |
| Additive D | 2 | Direct ATE | 850 | 850 mg/kg bodyweight |
| Unknown acute toxicity fraction | 8 | Manual unknown % | 8 | Not directly assigned |
| Estimated mixture ATE | About 89.63 mg/kg bodyweight, which falls in Category 3 for the oral route. | |||
Formula Used
Variable meanings
- Ci = concentration percentage of each relevant known ingredient.
- ATEi = direct route-specific ATE or category-converted point estimate.
- Cunknown = combined percentage of relevant ingredients with unknown acute toxicity.
| Route | Category 1 point | Category 2 point | Category 3 point | Category 4 point |
|---|---|---|---|---|
| Oral | 0.5 mg/kg | 5 mg/kg | 100 mg/kg | 500 mg/kg |
| Dermal | 5 mg/kg | 50 mg/kg | 300 mg/kg | 1100 mg/kg |
| Inhalation - Gas | 10 ppmV | 100 ppmV | 700 ppmV | 4500 ppmV |
| Inhalation - Vapor | 0.05 mg/L | 0.5 mg/L | 3 mg/L | 11 mg/L |
| Inhalation - Dust/Mist | 0.005 mg/L | 0.05 mg/L | 0.5 mg/L | 1.5 mg/L |
How to Use This Calculator
1. Select the route
Choose oral, dermal, or the correct inhalation form. This sets the unit, cutoffs, point estimates, and final hazard statement.
2. Enter known ingredients
For each relevant ingredient, enter its concentration and either a direct ATE or a hazard category. A direct value overrides category conversion.
3. Add unknown acute toxicity %
Use the unknown field for relevant ingredients lacking acute-toxicity data. Rows with concentration but no toxicity value are added there automatically.
4. Calculate the estimate
Press the calculate button. The result appears above the form and includes ATE, classification, signal word, hazard statement, and notes.
5. Review the graph
The Plotly graph shows which known ingredients dominate the toxicity denominator. Larger shares suggest stronger influence on the mixture estimate.
6. Export for reporting
Use CSV for data records and PDF for quick documentation. Always verify the result before using it in any compliance workflow.
8 FAQs
1. What does ATE mean here?
ATE is an estimated acute toxicity value used for route-based classification. Lower numbers indicate greater acute toxicity for the selected exposure route.
2. Should I enter a direct ATE or a category?
Use a direct ATE when you already have a tested or accepted converted value. Use a category when only the hazard category is available.
3. Why does unknown toxicity affect the result?
Unknown acute-toxicity ingredients can reduce confidence in the estimate. When the unknown fraction exceeds 10%, the calculator applies the adjusted numerator for classification screening.
4. Which inhalation option should I choose?
Choose gas, vapor, or dust/mist according to how the inhalation result is reported. Each one uses different units and different category thresholds.
5. Can this replace validated testing or expert review?
No. This is an educational estimation aid. Final labels, safety data sheets, and regulatory decisions should be reviewed by qualified professionals.
6. What if my total composition is below 100%?
Any remainder is treated as composition outside the acute estimate inputs, such as inert carrier or material not included in this screening calculation.
7. Why are category point estimates route-specific?
Acute-toxicity scales differ by exposure route. The same category therefore maps to different numerical point estimates for oral, dermal, and inhalation assessments.
8. What does the graph show?
The graph shows each known ingredient’s weighted contribution to the toxicity denominator. Larger shares mean that ingredient has stronger influence on the estimated hazard.